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Hard to Artemis was a virtual representation of one of Kassandra's genetic memories, relived by Layla Hassan through the Portable Animus HR-8.5.
Kassandra reached the outskirts of the Huntress Village on Chios and found that Bryce's information was correct.
Kassandra:The Daughters of Artemis are where Bryce said they'd be... The cave with the key must be nearby.
Ikaros scanned the area and found up to three caves in total; one just outside the north gate, another in the cliff wall on the western side of the village, and the last on the southern side.
Kassandra:Here we are. This looks like the place. This is it.
Kassandra made her way into one of the caves, faced the bear within, and found no disk within.
Kassandra:The key's not here. Must be in another cave.
She exited the cave and made her way to another. She faced another bear, but did not find the disk in that cave, either.
Kassandra:No key. I'll keep looking.
She deduced the key must be in the Cave of Arktoi, the cave on the southernmost side of the village. Kassandra crossed the village to infiltrate the cave.
(If Artemis's Request was completed by killing Daphnae)
Alternatively, a sentinel spotted Kassandra approaching the Cave of Arktoi and drew her blade.
Sentinel:Wolf meat approaches! Toned muscle—should keep the pack chewing for hours.
Kassandra:As the new Leader, the wolves will submit to my will.
Sentinel:You're not—
The sentinel looked up and saw Ikaros.
Sentinel:They sent word that the new leader was an eagle bearer.
Kassandra:Yes. I crushed Daphnae in ritual combat. Your life and your beasts belong to me.
Kassandra: Our pack. I defeated Daphnae in combat and earned her title.
Sentinel:No, there's no way you—
The sentinel looked up and saw Ikaros.
Sentinel:The Eagle Bearer... They sent word, but I didn't believe it.
Kassandra:We're family now, sister.
The sentinel looked at her intently, then sheathed her blade.
The quest can overlap with Clothes Make the Daughter, in that the Artemis Cave is one of the targets for both quests. If Ikaros highlights the cave while both quests are active, then both of Kassandra's comments tied to each highlight will play simultaneously.