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Revenge of the Wolf was a virtual representation of one of Kassandra's genetic memories, relived by Layla Hassan through the Portable Animus HR-8.5.
Kassandra headed south to the shrine mentioned by the woman. There, she came across several cages.
Kassandra:Hunting gear. The men were here.
Near the shrine, he found a bloodied body on the ground.
Kassandra:Found one... killed by the wolf. I wonder if this is the husband?
She investigated a trail of blood near the body.
Kassandra:Blood... The wolf must've dragged the other man. To a cave, maybe.
Kassandra followed the trail of blood to a nearby cave, where she found more blood trails and wolf's body.
Kassandra:It's huge! But if it's dead... what killed these men?
Kassandra entered the cave and found a wounded hunter lying on the ground.
Hunter:Who... who's there?
Kassandra:A woman sent me to kill a giant wolf and save her husband and his friend.
Hunter:I'm the friend. Her husband... he's dead. We killed a giant wolf, but she was full of pups. A terrible mistake. We didn't know...
They both heard a growl.
Kassandra:What's down there?
Hunter:We... um... finished skinning the she-wolf, then heard a sad and terrible howl. It was the mate! It tore into my friend, then dragged me here. It's waiting...
Kassandra:It wants revenge.
Hunter:You've got to kill it, or we die!
Kassandra:You killed its mate and unborn pups. It seems fair.
Hunter:What? No! Don't leave me. Don't leave me!
Kassandra turned and exited the cave, leaving the hunter to his fate. Before she was gone, she heard the wolf growl.
Hunter:No! Nice wolf! Nice wolf! No - Ahhhhhhhh!
Kassandra:For what you two did, I think it's time you and the wolf were reacquainted. Hunter, meet wolf. Wolf, eat hunter!
Hunter:What? No! You can't! You monster. You -
Kassandra turned and exited the cave, leaving the hunter to his fate. Before she was gone, she heard the wolf growl.
Hunter:No! Nice wolf! Nice wolf! No - Ahhhhhhhh!
Kassandra:I'm not here to judge—I was hired to kill a wolf. Wait here.
Hunter:Oh thank you. Thank you.
Kassandra headed further inwards, finding the giant wolf the hunter spoke of, and acquired its pelt.
Kassandra returned to the woman in Mytilene.
Civilian:My husband hasn't returned. Please tell me he's coming.
Kassandra:Your husband is dead.
Civilian:No!
Kassandra:But I killed the wolf and brought you its pelt. You can take comfort knowing he was avenged.
Civilian:Comfort? Avenged? My husband is dead. Nothing will ever change that fact! Take his helmet and leave!
Civilian:My husband... Where is he?
Kassandra:Your husband and his friend were killed by the giant wolf after he killed its mate and unborn pups. I chose not to kill it.
Civilian:No! I hired you to protect them. If I see you again, I'll put a contract on your head!
(If players received the pelt and talk to her after the mission.)
Despite its size, the wolf in the cave is not marked as an alpha animal. As such, it can be knocked out and tamed, which will still provide the Giant Wolf Skin item and complete the quest requirement to kill the wolf. Strangely, Kassandra is able to assassinate the wolf while it's tamed.