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Alexander the Great
Alexander III of Macedon, commonly known as Alexander the Great, was the Greek King of Macedon, and he was one of the most successful conquerors in history, including defeating the powerful Persian Empire. He is the most celebrated member of the Argead Dynasty and the creator of one of the largest empires in ancient history.
Alexander's explanation for success was a Piece of Eden: the Sword. In order to stop Alexander's misuse of the Sword and to acquire it for the Assassins, the Assassin Iltani poisoned Alexander, who died as a result on 10 or 11 June 323 BC.