User blog comment:Mwalsten/Who is Subject 16/@comment-817904-20100829191320

I don't think so. The closest link between Desmond and 16 that Lucy found was Ezio. And that was centuries in the past. So that would mean that the closest relative that they share, lived 100s of years in the past. In other words, they would be something along the lines of step brothers, but with 100s of years separating them.