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Ponte Sisto

The Ponte Sisto is a bridge spanning the Tiber River in Rome. During the Renaissance, it connected the Centro and Vaticano Districts.
Database entry
The current incarnation was built by Pope Sixtus IV between 1473 and 1479 as a replacement for its predecessor, Pons Aurelius. What sets this bridge apart from the rest is its central stylized occulus, which I think looks quite sharp.