Mary I of England
Mary I (18 February 1516 – 17 November 1558) was Queen of England and Queen of Ireland from 19 July 1553 until her death. She was the eldest daughter of Henry VIII and the only surviving child of Catherine of Aragon.
As the 4th crowned monarch of the Tudor dynasty, she is remembered for restoring England to Roman Catholicism after succeeding her short-lived half brother, Edward VI, to the English throne. In the process, she had almost 300 religious dissenters burned at the stake in the Marian Persecutions, earning her the sobriquet of "Bloody Mary". Her re-establishment of Roman Catholicism was reversed by her successor and half-sister, Elizabeth I.
Assassin's Creed
In the Assassin's Creed universe, she possessed "The Apple", a Piece of Eden. In her death, her half-sister and successor, Elizabeth I, acquired the Piece of Eden to reverse her sister's re-establishment of Roman Catholicism, just like in real life.