Manuel

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Manuel may refer to:

• Manuel I of Portugal, the 14th King of Portugal who allied himself with the Templars in Assassin's Creed: Brotherhood
• Manuel Palaiologos, heir to the Byzantine Empire throne and a character in the upcoming game Assassin's Creed: Revelations
• Manuel Tadros, a Canadian voice actor who provides the voice for Rodrigo Borgia in Assassin's Creed: Lineage, Assassin's Creed II, and Assassin's Creed: Brotherhood