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Delizia di Belriguardo
Delizia di Belriguardo was a palazzo near the city of Ferrara, owned by Lucrezia Borgia's third husband, Alfonso d'Este, the Duke of Ferrara.
Ezio Auditore traveled to the castle in order to find one of Leonardo da Vinci's five lost paintings. When Ezio managed to enter, he seduced Lucrezia, who willingly gave him the painting. He tied her to a post, prompting Lucrezia to call the guards. Ezio successfully escaped with the painting.
Trivia

- Interestingly, there are only banners with the Borgia coat of arms on them inside and outside of the palazzo, even though the Borgia didn't own it, nor did they hold any more power.