Ezio Auditore travelled to the castle, which was inhabited by Lucrezia Borgia, in order to find one of Leonardo da Vinci's five lost paintings. When Ezio managed to enter, he seduced Lucrezia, who willingly gave him the painting. He tied her to a post, prompting Lucrezia to call the guards. Ezio successfully escaped with the painting.
Trivia
Interestingly, there are only banners The palazzo gardens.with the Borgia clan crest on them inside and outside of the palazzo, even though the Borgia didn't own it, nor did they hold any more power.
