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Cleopatra
Cleopatra VII Philopator was the last effective Pharaoh of the Ptolemaic dynasty of Egypt. At first, she shared power with her father and later her brothers, whom she married. She eventually got sole control and started a liason with Gaius Julius Caesar, who she had a child with: Caesarion.
After Julius Caesar's death, she alligned herself with Marcus Antonius, who she also had children with. Antonius eventually commited suicide after losing the Battle of Actium.
Soon after, Cleopatra was assassinated by Amunet, who used a snake. However, the history books claimed she commited suicide.