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User blog comment:Subject 16*/Assassin's Creed: Revelations - News/@comment-58.69.93.16-20110506101557/@comment-60.230.198.87-20110508163202
Im not sure if you know this but a male never stops producing sperm (well until you die that is). Women stop producing eggs in their late 50's. So yes Ezio can still make a baby.
PS. He will be in his late 50's, the game is set at least 10 years after the events of Brotherhood and will likely continue for a few years, past Da Vinci's death. I don't see Ezio killing everybody on the list in a year soooooo...... yeah