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User blog comment:Master Sima Yi/Assassin's Creed: Project Legacy announced/@comment-2152155-20101001202514/@comment-1153722-20101001202911
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It most likely is. Nothing hints to it being non-canonical. Chapter 1 is about Bartolomeo during the Battle of Agnadello and the questions Abstergo asks you after it hint to Bartolomeo's motives actually being a Piece of Eden, just like in AC II's database entry.
Why would it be non-canonical anyways?