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Papacy
The Papacy is the office of the pope. Besides its religious role as the official catholic order, it acted as a government ruling over a large part of Italy (of which only remains today the Vatican city-state enclaved in Rome). Its capital was Rome.
In Assassin's Creed II, Rodrigo Borgia becomes the Pope, giving him the power of the entire European Christiendom. He could of easily found and killed Ezio from the beginning of his Papacy, but why he didn't is unknown.