Minerva

Minerva was a member of Those Who Have Gone Before who was also known as Merva, and Mera, and so on, before her death. She appears as a hologram within The Vault, and reveals a little of the history of humanity and her people's origins.

She explains the disaster the Earth suffered, and specifically referred to Ezio as the "prophet"; she revealed that she was not speaking to him, but through him. Minerva apparently knew that Desmond was reliving Ezio's memories as she said "the rest is up to you Desmond", much to his ancestor's confusion.