Genghis Khan
Genghis Khan (c. 1162 – 1227) was a Mongolian warlord, born by the name of Temujin. He was the son of a tribal leader, though he became an outcast after his father's death. Temujin united the Mongol tribes and marched on China. He conquered much of central Asia, southern Russia, the middle east, and parts of Eastern Europe. He founded the Mongol Empire, which he reigned from 1206 until his death in 1227.
The Grand Master of the Syrian Assassin sect, Altaïr Ibn-La'Ahad had heard of him and suspected him to wield "The Sword," a Piece of Eden that granted military and combat prowess. He and his family traveled East, where he trained his sons to kill Genghis Khan, as Altaïr himself was too old at the time. In 1227, the Assassin Qulan Gal shot Genghis Khan's horse, causing the warlord to fall off and die.
In real life, Genghis Khan fell off his horse and later died of his injuries. It is unknown what caused him to fall in the first place, though popular belief is that it was battle fatigue.
Genghis' grandson Hulagu Khan destroyed most of the Assassin's strongholds after a failed assassination in 1256 and effectivly destroyed the Assassin's power in the East.