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Dual-wielding
In Assassin's Creed: Brotherhood, Ezio Auditore is able to dual-wield weapons during combat. The pistol acts as a dual weapon to the primary weapon, and (similarly to the original Assassin's Creed) the throwing knives act as dual weapons for the short blade. If you have a normal weapon, hold the attack button to aim. You can also fire poison using the poison blade when you buy it from Leonardo.
Dual-wielding weapons offer many more types of counter kills and finishing moves, as well as allowing the player to smoothly shift between long-range and short-range attacks.